Anchor institutions are large public organizations rooted in their communities with widespread impacts. They are unlikely to relocate, with sustained influence over time. They operate with significant economic, environmental, and human resources. Due to their reach, these organizations always influence the social, economic, and environmental determinants of health in their communities. An intentional approach to these impacts can can leverage procurement, training, employment, professional development, buildings, and land-use choices to support their local community’s health, wellbeing, and economy, and mitigate social and health inequities.